The number, cumulative total duration and mean duration of SWDs were significantly higher in GAERS compared to WAG/Rij, while the discharge frequency was higher in the WAG/Rij. This study aimed a systematic and detailed comparison of the SWD patterns of both strains in terms of the intensity, frequency and waveform morphology of the discharges by using exactly the same measurement and analysis techniques. Although they share similar characteristics including the spike-and-wave discharges (SWDs) in the EEG, some differences have been reported between both strains. The inbred Wistar Albino Glaxo Rats from Rijswijk (WAG/Rij) and the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are well-validated genetic models of absence epilepsy. Acibadem Mehmet Ali Aydinlar University Affiliated: No.Keywords: WAG/Rij, GAERS, Spike-and-wave discharges, Power spectrum, Frequency domain, Waveform morphology, SPIKE-WAVE DISCHARGES, IDIOPATHIC GENERALIZED EPILEPSY, GENETIC MODEL, SEIZURES, EEG, MECHANISMS, PHENOTYPES, THALAMUS, STRAIN.Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus.
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